Two cell theory ovarian steroidogenesis

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For all types of ovarian cancer, the five-year survival rate is 44 percent. Younger women have a higher survival rate than older women. Women diagnosed with early-stage ovarian cancer — specifically, stage 1 ovarian cancer — have a higher survival rate than women diagnosed with late-stage ovarian cancer. If ovarian cancer is found in stage 1, 92 percent of patients have a five-year survival rate. Unfortunately, only 15 percent of ovarian cancers are diagnosed at this stage. Fortunately, according to statistics from the CDC, rates of ovarian cancer have generally decreased the last 10 years.

Dr. Vogt is a Professor in the Department of Molecular and Experimental Medicine at The Scripps Research Institute in La Jolla, California. He has received many awards and honors, including the Gregor Johann Mendel Medal, Charles S. Mott Prize, Ernst Jung Prize for Medicine, Bristol Meyers Award, and ICN International Prize in Virology. Dr. Vogt has been invited as a distinguished lecturer by more than twenty leading research institutions in the US, Europe, and Asia, among them the German Cancer Research Center in Heidelberg for the Meyenburg Foundation Lecture, the Princess Takamatsu Foundation, the Alexander von Humboldt Foundation of the Federal Republic of Germany and the Agency for Science, Technology and Research of Singapore. He was also elected an Honorary Member of the Japanese Cancer Association and received an honorary doctorate from the University of Würzburg. Dr. Vogt is an elected member of many prestigious academies, including the American Academy of Arts and Sciences, the National Academy of Sciences, the Institute of Medicine of the National Academies, and the American Academy of Microbiology. He is the recipient of the 5th Annual Szent-Györgyi Prize for Progress in Cancer Research.

It has recently been recognized that carcinogenesis of endometrioid and clear cell carcinomas arising from endometriotic cysts is significantly influenced by the microenvironment in which the tumor arises [ 34 ]. As the content of an endometriotic cyst includes highly concentrated old blood, the concentration of iron is markedly high in endometriotic cysts [ 35 ]. Free iron is associated with cancer development through the induction of persistent oxidative stress. The epithelial cells within the endometriotic cyst are exposed to extensive oxidative stress (reactive oxygen species (ROS)) and hypoxia, and, as a result, they are subjected to more cellular and DNA damage and have less efficient DNA repair [ 36 , 37 ].

Two cell theory ovarian steroidogenesis

two cell theory ovarian steroidogenesis

It has recently been recognized that carcinogenesis of endometrioid and clear cell carcinomas arising from endometriotic cysts is significantly influenced by the microenvironment in which the tumor arises [ 34 ]. As the content of an endometriotic cyst includes highly concentrated old blood, the concentration of iron is markedly high in endometriotic cysts [ 35 ]. Free iron is associated with cancer development through the induction of persistent oxidative stress. The epithelial cells within the endometriotic cyst are exposed to extensive oxidative stress (reactive oxygen species (ROS)) and hypoxia, and, as a result, they are subjected to more cellular and DNA damage and have less efficient DNA repair [ 36 , 37 ].

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