Uveitis : Controlled clinical studies of patients with uveitis demonstrated that LOTEMAX (loteprednol etabonate ophthalmic suspension) was less effective than prednisolone acetate 1%. Overall, 72% of patients treated with LOTEMAX (loteprednol etabonate ophthalmic suspension) experienced resolution of anterior chamber cell by day 28, compared to 87% of patients treated with 1% prednisolone acetate. The incidence of patients with clinically significant increases in IOP ( ≥ 10 mmHg) was 1% with LOTEMAX (loteprednol etabonate ophthalmic suspension) and 6% with prednisolone acetate 1%.
These eye drops and ointments contain a combination of a steroid and one or more types of antibiotic for treatment of infection and inflammation of the eye. The steroid reduces inflammation while the antibiotic treats or prevents infection which may be the cause of the infection. Examples of steroids that are used in these eye drops are hydrocortisone, loteprednol, prednisolone, and dexamethasone . Examples of antibiotics used in these formulations include tobramycin, neomycin, bacitracin, polymixin B, and gentamycin. These antibiotics have different mechanisms of action and two or three may be combined in one formulation.
Prostaglandin analogs may cause changes in iris color and eyelid skin, growth of eyelashes , stinging, blurred vision , eye redness, itching, and burning. Beta blockers' side effects include low blood pressure , reduced pulse rate , fatigue , shortness of breath, and in rare occasions, reduced libido and depression . Alpha agonists can cause burning or stinging, fatigue, headache , drowsiness , dry mouth and nose , and also they have a higher likelihood of allergic reaction. Carbonic anhydrase inhibitors may cause stinging, burning, and eye discomfort.