Steroids cause leukemia

Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

The other offender in causing left side pain in the lower area of the back is the gallbladder. The gallbladder stores bile that is produced by the liver and this helps the body with food digestion. Problems with your gallbladder are fairly common in industrialized societies. The refined and processed food eaten in these cultures takes a heavy toll on the gallbladder. Recent studies show that over a million Americans have gallstones can have gall stones or a diseased gallbladder and the result is almost always the same. Remove the gallbladder and you remove the pain.

Steroids cause leukemia

steroids cause leukemia


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