Ashwagandha decreases inflammation. There are many scientific studies all backing this claim. The mechanisms for decreasing inflammation as far as ashwagandha supplementation is concerned are not totally understood yet, but the cortisol reducing properties may be largely responsible. Cortisol, when released in small and “normal” levels, is actually a good thing. It can help to reduce inflammation and prime the body to deal with the major stressors that life throws at us. But our cortisol levels are often way too high in the modern world. We need to reduce them and bring them to a balanced state for optimal health.
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Isolation of a new saponin and cytotoxic effect of
saponins from the root of Platycodon grandiflorum on human tumor cell lines.
Planta Med. 2005.
A novel triterpenoid saponin, deapioplatycoside E was isolated from the root extract of Platycodon grandiflorum, together with the seven known saponins, i. e., platycoside E, deapioplatycodin D3, platycodin D3 (4), polygalacin D2 (5), platycodin D2 (6), deapioplatycodin D (7) and platycodin D (8). The crude saponin fraction (ED50: ca. 10 - 15 microg/mL) and compounds 6 - 8 exhibited significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.