Steroid receptor action

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

When considering off-season use of Trenbolone Enanthate, there is something we must keep in mind. Use will help the individual control his body fat, but this does not mean body fat is impossible to gain. You must consume a level of calories above maintenance to truly grow. Thankfully, with Tren you will make better use of each calorie and the metabolic factors will also provide fat gain protection. However, there will still be a cutoff point. The use of Tren in the off-season is not a license to eat like there’s no end in site. You can still gain plenty of body fat if you don’t exercise self-control.

Steroid receptor action

steroid receptor action

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