An ointment of the present invention as prepared in Example 1 was tested in a bilateral paired psoriasis study using a conventional betamethasone 17,21-dipropionate ointment consisting of mg/g betamethasone 17,21-dipropionate, mg/g mineral oil and mg/g white petrolatum. Results of the bilateral paired comparison study [P values based on two-tailed sign test] indicate the ointment of Example 1 to be significantly (p ≤ ) more effective than the conventional ointment in the treatment of patients with chronic, stubborn psoriasis, based on the following results:
Transdermal patches can be a very precise time released method of delivering a drug. Cutting a patch in half might affect the dose delivered. The release of the active component from a transdermal delivery system (patch) may be controlled by diffusion through the adhesive which covers the whole patch, by diffusion through a membrane which may only have adhesive on the patch rim or drug release may be controlled by release from a polymer matrix. Cutting a patch might cause rapid dehydration of the base of the medicine and affect the rate of diffusion.