Hodgkin's lymphoma is a lymphoma of B cell origin that occurs worldwide. Specific subtypes of Hodgkin's lymphoma, (mixed cellularity and lymphocyte-depleted), are more commonly associated with EBV infection. EBV-positive Hodgkin's disease may comprise up to 65% of all cases. It is now clear that not only is infectious mononucleosis a risk factor (RR=) for the development of Hodgkin's lymphoma, but that infectious mononucleosis does not increase the risk of EBV-negative Hodgkin's disease. The median interval to the diagnosis of Hodgkin's disease after symptomatic infectious mononucleosis was years in a large recent study ( 53 ).
Major depressive disorder is a complex disease and most currently available antidepressants aiming at monoamine neurotransmission exhibit limited efficacy and cognitive effects. N-methyl-D-aspartate (NMDA), one subtype of glutamate receptors, plays an important role in learning and memory. N-methyl-D-aspartic acid (NMDA) enhancing agents, such as sarcosine (N-methylglycine), have been used as adjunctive therapy of schizophrenia. Preliminary clinic trials indicated that intake of sarcosine improved not only psychotic but also depressive symptoms in patients with schizophrenia.