Anabolic amplifier dhb

Grapefruit juice can increase the oral bioavailability of a broad range of medications [8] as it produces mechanism-based inhibition of intestinal drug metabolism when consumed [9]. As mentioned before 6′,7′-dihydroxybergamottin has been identified as probable active constituent responsible for grapefruit juice effect [10]. However, studies report that it is not the major active ingredient, although it largely contributes to the grapefruit juice-felodipine interaction [10,11]. A study published on [12] concluded that grapefruit juice (but not 6′,7′-DHB) increased concentration of cyclosporine probably because intestinal P-glycoprotein may be a more important determinant of cyclosporine availability than inhibition of cytochrome P450 CYP3A4. Studies suggest that grapefruit juice also affects, but only to a minor extent, the modulation of P-glycoprotein function [12,15,16].

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Anabolic amplifier dhb

anabolic amplifier dhb

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