Grapefruit juice can increase the oral bioavailability of a broad range of medications  as it produces mechanism-based inhibition of intestinal drug metabolism when consumed . As mentioned before 6′,7′-dihydroxybergamottin has been identified as probable active constituent responsible for grapefruit juice effect . However, studies report that it is not the major active ingredient, although it largely contributes to the grapefruit juice-felodipine interaction [10,11]. A study published on  concluded that grapefruit juice (but not 6′,7′-DHB) increased concentration of cyclosporine probably because intestinal P-glycoprotein may be a more important determinant of cyclosporine availability than inhibition of cytochrome P450 CYP3A4. Studies suggest that grapefruit juice also affects, but only to a minor extent, the modulation of P-glycoprotein function [12,15,16].
Salary by Job : A B C D E F G H I J K L M N O P Q R S T U V W X Y Z