Abrupt discontinuation of steroids

All depression drugs can potentially lead to discontinuation symptoms, but some are much more likely to do so than others. In fact, antidepressant labels often warn that stopping the medication too quickly may lead to bothersome symptoms. However, discontinuation symptoms are more likely with antidepressants that stay in your body for a shorter period of time, especially those that affect both serotonin and norepinephrine, such as Effexor ( venlafaxine ) and Cymbalta ( duloxetine ). Other short-acting medications that affect mainly serotonin include:

Multiple case reports demonstrate that antidepressant discontinuation syndrome associated with tricyclic antidepressants closely mimics that of the SSRIs. 3 , 4 However, signs of parkinsonism and profound problems with balance appear to be especially characteristic of antidepressant discontinuation syndrome caused by tricyclic antidepressant discontinuation. 3 , 4 Additionally, case reports have noted that the antidepressant discontinuation syndrome associated with MAOIs may involve more serious symptomatology such as aggressiveness, agitation, catatonia, severe cognitive impairment, or myoclonus and psychotic symptoms and may require more intensive management. 4 , 5

Abrupt discontinuation of steroids

abrupt discontinuation of steroids

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